Bioprotocols online

Sciclips has launched a unique database of bioprotocols for global researchers. Researchers will have free access to these bioprotocols which have been extracted from published journal articles and patents/patent applications. We are the first to list protocols from published US patents, US patent and WO (PCT) applications. We have thousands of protocols on molecular biology, proteomics, biological imaging, virology, immunology, stem cells, drug Discovery, immunoassays, cell biology, epigenetics, genomics, plant biology, microbiology, tissue microarrays and more. In addition to this, we have also listed new sections on high throughput screening (HTS) and biopharmaceutical assay protocols. All the protocols are linked to the articles or patent/patent applications. These unique collections of bioprotocols will help researchers not only to search for the right reference but also to use them most effectively in their daily research activities. This would help in reducing time for setting up experiments and writing an article or grant applications. Researchers can also submit their published protocols in our database through our interactive submission form. Please follow this link to see the complete list of our bioprotocols online: http://www.sciclips.com/sciclips/bio-protocols.do

Are you working with cell-based techniques and looking for the best transfection reagents to achieve high efficiency and low toxicity? You must be debating upon which transfection reagent to choose. Well, Sciclips has launched a site with information on most cited research reagents and kits that are currently available in the market. This site provides the researcher to find out the most popular reagents in the market. The current research reagent/kits listings are: Transfection reagents, RT-PCR, Real-time PCR, RNA purification, cAMP assays, Cytotoxicity assays and Western blot reagents. The data is generated from recent published articles, patents and patent applications. Please visit the following site to see the details: http://www.sciclips.com/sciclips/most-cited reagents.do?cat=TransfectionReagents\&catId=1501

Are current cell-based assays are truly reliable for drug screening?

Drug discovery is an expensive and a long term process. Though, the technology for drug screening is evolving everyday but only very limited number of drug candidates qualify for the final screening and get approved by FDA. We can see a drastic decline in new drug candidates in the past few years. This is mainly due to the low efficacy and toxicity of the drug on human system.
Cell-based assays are widely used for drug screening and have become powerful tools in the past decade. These cell-based assays are used in cytotoxicity, cAMP assay, ADME/Tox, GPCR, kinase assays etc. Usually, these in-vitro assays are performed in a multi-well microtiter plate. Mammalian cells are cultured in these plates and incubated with the drug for a specific period of time. The viability of the cells were then measured which correlates the toxicity level of the drug. Predictability of these assays are not at all satisfactory as in many cases the drugs fail in the human system, as the in-vitro studies are very different from the biological process inside our body.

More: http://www.sciclips.com/sciclips/blogMain.do