Raman Spectroscopy (Biomarker,Drug Discovery and Theranostics Applications) Protocols

A comprehensive list of bioprotocols related to the applications of Raman spectroscopy in biomarker discovery/imaging, cancer diagnosis, drug efficacy evaluation, drug composition analysis, protein/DNA/metabolite analysis, drug discovery assays and theransotics. The methods include coherent anti-Stokes Raman scattering (CARS),surface enhanced Raman spectroscopy (SERS),Tip-enhanced Raman scattering (TERS) etc. This unique list of protocols are linked to open access journal articles, patents (issued) and patent applications. Link: http://www.sciclips.com/sciclips/bio-protocols.do

Nanoparticles: Drug delivery, Imaging and Theranostics Protocols

A comprehensive list of bioprotocols related to nanoparticle based Drug delivery & assays/immunoassays/imaging and preparation & characterization. This unique list of protocols are linked to open access journal articles, patents (issued) and patent applications. Link: http://www.sciclips.com/sciclips/bio-protocols.do

Next Generation Sequencing Bioprotocols and Bioinformatics Tools

Next Generation Sequencing Protocols: A comprehensive list of next generation sequencing protocols for human, bacteria, virus, plants and other organisms.Link: http://www.sciclips.com/sciclips/bio-protocols.do

Next Generation Sequencing Bioinformatics Tools & Databases: A comprehensive list of open access bioinformatics tools and database for next generation sequencing data analysis. Link: http://www.sciclips.com/sciclips/bio-protocols.do

Recent Oncology Drug Discovery and Drug Delivery Patents

Following are the highlights of recent US patent applications related to cancer drug discovery. Details of each patent application with link to respective patents are available in the website.

1. Targeted drug delivery of liposome encapsulated drugs with cancer-targeting peptides for breast cancer therapy
2. miR-31 as a therapeutic drug target of breast cancer
3. Combination therapy for non-small cell lung cancer (NSCLC) using choline kinase inhibitors
4. Tumor marker protein SIMA135 for cancer diagnostic therapy (theranostics)
5. In vitro method for producing colorectal cancer cell derived microtumors
6. AMPK activator for the treatment of cancer having an aberrant EGFR or KRAS genotype
7. Screening phage-displayed antibodies that bind to radiation-inducible targets
8. BRCA1 based selection of treatment strategy for breast cancer, ovarian cancer and prostate cancer patients
9. mAR s a therapeutic target for enhancing the effectiveness of chemotherapy in glioblastoma patients
10. Peptide modified metal nanoparticle bioconjugates targeting GIPC/synectin for the treatment of cancer
11. New FGFR kinase inhibitors for the treatment of cancers expressing FGFR or PDGFR mutants
12. Fluorescent lymphatic mapping for sentinel lymph node (SLN) biopsy procedure
13. UV-controlled doxorubicin release from liposomes
14. RTD protein – a novel therapeutic modulator of apoptosis
15. PASD1 protein as a cancer vaccine target for B-cell tumours
16. TNF superfamily cytokines fused with collectin family trimerization domain for the treatment of cancer and other diseases

Link: http://www.sciclips.com/sciclips/drug-discovery-news.do

Recent Oncology Biomarker Patents

Highlights of recent US patent applications on cancer biomarkers.

1. New predictive biomarker of response to cetuximab in metastatic colorectal cancer patients
2. Predictive biomarker of response to combination therapy in metastatic colorectal cancer patients
3. Endocan as a serum biomarker of sepsis
4. Gene expression markers for diagnosis and prognosis of lung cancer
5. BRCA Ashkenazi mutation specific antibody test for breast cancer
6. BRCA tissue truncation test for the diagnosis of breast cancer

Details: http://www.sciclips.com/sciclips/biomarker-news.do

Recent Patent Applications on Next Generation Sequencing

Following are the highlights of recent patent applications on next generation sequencing. Complete review of next generation sequencing related patent searches and data mining are available through Sciclips consultancy services: http://www.sciclips.com/sciclips/consultancy.do.

1. Terminal tagging oligoribonucleotide (rTTO) to join a DNA sequence tag to the 3′-termini of first-strand cDNA molecules
2. A ligation-based method and a kit for preparing a template for next generation sequencing
3. Next generation sequencing method for noninvasive prenatal diagnostics
4. High-throughput next generation sequencing DNA markers for treating, diagnosing, and prognosing lung cancer
5. Next generation sequencing method of predicting the risk of a patient for developing COX-2 inhibitor lumiracoxib induced hepatotoxicity
6. Next generation sequencing method for determining the primary site of a cancer of unknown primary site (CUP)
7. Next generation sequencing method for diagnosing Noonan-like syndrome with loose anagen hair
8. Next generation sequencing method for the diagnosis of Alzheimer’s disease
9. Method for high throughput paired-end sequencing of large-insert clone libraries for next generation sequencing
10. Next generation sequencing method for determining the increased risk for developing degenerative neurological or psychiatric diseases
11. Identification of fetal nucleic acid fraction in a mixture of fetal and maternal nucleic acids using next generation sequencing
12. Next generation sequencing method for predicting the risk of developing late onset Alzheimer’s disease
13. Whole genome sequencing methods for identifying polymorphisms in blood sample
14. Next generation sequencing methods for diagnosing presence or increased risk of developing an autism spectrum disorder
15. Next generation sequencing method for determining the genome of an unborn fetus of a pregnant female

Details: http://www.sciclips.com/sciclips/biomarker-news.do