Following are the highlights of recent US patent applications related to cancer drug discovery. Details of each patent application with link to respective patents are available in the website.
1. Targeted drug delivery of liposome encapsulated drugs with cancer-targeting peptides for breast cancer therapy
2. miR-31 as a therapeutic drug target of breast cancer
3. Combination therapy for non-small cell lung cancer (NSCLC) using choline kinase inhibitors
4. Tumor marker protein SIMA135 for cancer diagnostic therapy (theranostics)
5. In vitro method for producing colorectal cancer cell derived microtumors
6. AMPK activator for the treatment of cancer having an aberrant EGFR or KRAS genotype
7. Screening phage-displayed antibodies that bind to radiation-inducible targets
8. BRCA1 based selection of treatment strategy for breast cancer, ovarian cancer and prostate cancer patients
9. mAR s a therapeutic target for enhancing the effectiveness of chemotherapy in glioblastoma patients
10. Peptide modified metal nanoparticle bioconjugates targeting GIPC/synectin for the treatment of cancer
11. New FGFR kinase inhibitors for the treatment of cancers expressing FGFR or PDGFR mutants
12. Fluorescent lymphatic mapping for sentinel lymph node (SLN) biopsy procedure
13. UV-controlled doxorubicin release from liposomes
14. RTD protein – a novel therapeutic modulator of apoptosis
15. PASD1 protein as a cancer vaccine target for B-cell tumours
16. TNF superfamily cytokines fused with collectin family trimerization domain for the treatment of cancer and other diseases
Link: http://www.sciclips.com/sciclips/drug-discovery-news.do
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