This scientific blog critically analyzes potential
complexities associated with current biomarker discovery approaches. According
to the scientific arguments that have been put forward in this blog, thousands
of biomarkers that are currently being reported may not be true biomarkers of
the target disease, rather it may be a complex mixture of biomarkers, which may
include target disease specific biomarker as well as biomarkers or biomolecules
associated with other diseases, infections, gender, race/ethnic backgrounds,
geographic-environmental factors, psychiatric condition/diseases and
nutritional factors. Based on our
analysis, we believe that an ideal biomarker discovery platform, which can lead
to the development of reliable and robust diagnostics assays, should be
developed by integrating comprehensive understanding of patients’ phenotypic,
genetic and socio-environmental characteristics along with biological and
functional relevance of all biomolecules that may be potentially identified and
called as biomarkers. Several innovative strategies for developing rational and
personalized biomarker discovery platforms have been suggested in this blog. These
strategies include 1) Comprehensive
genome-scale analysis based rational genetic biomarker discovery 2) Cell
or tissue or organ specific function based rational or targeted biomarker
discovery 3) Use of validated
tissue/organ specific biomarkers or therapeutic drug targets for identifying
non-invasive biomarkers, 4) Epidemiology-driven
biomarker discovery for developing personalized diagnostic tools and 5)
Integrated bioinformatics approaches for rational biomarker discovery. The
relevance of disease prevalence and predictive value in biomarker discovery for
personalized medicine, utility of rational or personalized biomarkers in
clinical trials and applications of rationally identified biomarkers for
diagnostics imaging or theranostics have also been discussed. Link to the full
blog: http://www.sciclips.com/sciclips/blogArticle.do?id=1021&blog=Strategies%20for%20Rational%20and%20Personalized%20Cancer%20Biomarker%20Discovery
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