Recent Drug Discovery and Biomarker Research Highlights

Drug discovery

1. Induced pluripotent stem cell based human cellular model for Rett syndrome
2. Water drinking could assist overweight children in weight loss
3. Organic cation transporter 2 (OCT2) as potential pharmacological target for mood disorders therapy
4. HDAC6 inhibitors for the treatment of Charcot-Marie-Tooth disease
5. Protein complementation with resonance energy transfer to study conformational changes in response to activation of a GPCR heteromer
6. STAT3 pathway as a therapeutic drug target of prostate cancer stem cells
7. A prodrug approach for improving tuberculosis drug targets
8. Novel thalidomide derivatives for the treatment of sickle cell diseases
9. Novel isoniazid derivatives for the treatment of tuberculosis
10. iPS cells derived neural stem cells for glioma gene therapy
11. Identification galactose-1-phosphate uridyltransferase (GALT) inhibitors for classic galactosemia treatment
12. Potent inhibitors of dihydroorotate dehydrogenase (DHODH) for the treatment of malaria
13. Promising reversible and selective MAO-B inhibitors identified
14. A screening strategy to identify drugs that suppress statin muscle toxicity
15. Fluorescent sensors to study cell signaling molecules with high spatial and temporal resolution
16. Anti-progastrin antibody for the treatment of breast cancer and colorectal cancer
17. Plasminogen activator inhibitor-1derived peptides for the treatment of asthma
18. Parstatin peptide for the treatment of myocardial ischemic injury
Details: http://www.sciclips.com/sciclips/drug-discovery-news.do


Biomarkers

1. Multidrug resistance (MDR) gene signatures as prognostic biomarkers of ovarian cancer
2. Urinary metabolomic biomarkers of broccoli and Brussels sprouts consumption
3. Protein standard absolute quantification (PSAQ) method for the measurement of cellular ubiquitin pools
4. Proteins associated with aggressive prostate cancer identified
5. Urinary NGAL a promising early marker for monitoring renal impairment in patients with short-term type 2 diabetes
6. Novel glycan biomarkers of colon cancer
7. REGIV as a biomarker of peritoneal recurrence after curative resection in gastric cancer patients
8. Biomarker panel for the diagnosis of live injury
9. kPCR assay for the detection of KRAS and PIK3CA mutations in colorectal cancer
10. Urinary metabolomic biomarkers for the diagnosis of prostate cancer
11. In vivo imaging of ADLH in cancer stem cells
12. EML4-ALK gene or protein fusion as a biomarker for the diagnosis of non-small cell lung cancer
13. Progastrin as a biomarker for the diagnosis of breast cancer
14. Progastrin as a biomarker for the diagnosis of liver cancer, cirrhosis, and hepatitis C
15. MAGEC2- a biomarker for the differential diagnosis of testicular germ cell tumors
16. PRDM1 protein a potential biomarker of radiation therapy–induced secondary malignancies in pediatric Hodgkin's lymphoma
17. Genetic variations in chromosome 11 to predict schizophrenia risk
18. GRP78 SNP as a predictive biomarker of liver cirrhosis in persistent HBV carriers
Details: http://www.sciclips.com/sciclips/drug-discovery-news.do